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Test Code PUPYU Purines and Pyrimidines Panel, Random, Urine

Important Note

This test is only orderable by the laboratory.  To request this test in EPIC, please order LAB001 MAYO MISCELLANEOUS TEST.  Fill out appropriate prompts and request the Mayo test code listed above.

If you need further assistance, please contact the laboratory at 406-414-5010.

Useful For

Evaluating patients with symptoms suspicious for disorders of purine and pyrimidine metabolism

 

Monitoring patients with disorders of purine and pyrimidine metabolism

 

Laboratory evaluation of primary and secondary hyperuricemias

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Specimen Type

Urine


Ordering Guidance


This is recommended screening test for the initial workup of a suspected disorder of purine and pyrimidine metabolism, particularly when clinical features are nonspecific, and includes measurement of purines, pyrimidines, uric acid, and S-sulfocysteine. If the clinical features are suggestive of molybdenum cofactor deficiency, isolated sulfite oxidase deficiency, and hereditary xanthinuria, order SSCTU / S-Sulfocysteine Panel, Urine.

 

If this test is ordered with SSCTU, then SSCTU will be canceled.

Necessary Information


Patient's age is required.



Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 3 mL

Collection Instructions: Collect a random urine specimen.


Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen 90 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

Age range 

0-3 years

4-6 years

7-12 years

13-18 years

>18 years

Uracil

≤50

≤30

≤25

≤20

≤20

Thymine

≤3

≤3

≤3

≤3

≤3

Adenine

≤3

≤3

≤3

≤3

≤3

Hypoxanthine

≤65

≤30

≤30

≤30

≤30

Xanthine

≤54

≤21

≤35

≤15

≤20

Orotic

≤4

≤4

≤3

≤3

≤5

Dihydroorotic acid

≤3

≤3

≤3

≤3

≤3

Uric Acid

350-2500

200-2000

200-1400

150-700

70-700

Deoxythymidine

≤3

≤3

≤3

≤3

≤3

Deoxyuridine

≤3

≤3

≤3

≤3

≤3

Thymidine

≤3

≤3

≤3

≤3

≤3

Uridine

≤10

≤3

≤3

≤3

≤3

Deoxyadenosine

≤3

≤3

≤3

≤3

≤3

Deoxyinosine

≤3

≤3

≤3

≤3

≤3

Deoxyguanosine

≤3

≤3

≤3

≤3

≤3

Adenosine

≤3

≤3

≤3

≤3

≤3

Inosine

≤6

≤3

≤3

≤3

≤3

Guanosine

≤4

≤3

≤3

≤3

≤3

5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR)

≤3

≤3

≤3

≤3

≤3

Succinyladenosine

≤16

≤3

≤3

≤3

≤3

S-Sulfocysteine

≤11

≤5

≤5

≤5

≤5

Dihydrouracil

≤15

≤6

≤6

≤6

≤6

Dihydrothymine

≤11

≤3

≤3

≤3

≤3

N-Carbamoyl-B-alanine

≤30

≤10

≤10

≤10

≤10

N-Carbamoyl-B-aminoisobutyric
acid

≤20

≤3

≤3

≤3

≤3

 

All results reported as mmol/mol creatinine

Day(s) Performed

Tuesday, Thursday

Report Available

3 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542