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Test Code LAB1887 Myeloproliferative Neoplasm Panel

Useful For

Detecting genetic abnormalities associated with cancer

Profile Information

Test Name

Test Components
Polycythemia Vera (PV) JAK2 V617F, reflex to JAK2 Exons 12-14
Essential Thrombocythemia (ET) JAK2 V617F, reflex to CALR, reflex to MPL
Primary Myelofibrosis (PMF) JAK2 V617F, reflex to CALR, reflex to MPL

 

Methodology

Molecular

Performing Laboratory

Yellowstone Pathology Institute

Specimen Requirements

Specimen Type: Bone Marrow Aspirate

Container/Tube: EDTA (lavender top)

Specimen Volume: 2 mL

Collection Instructions:

  1. Invert several times to mix bone marrow.
  2. Send specimen at ambient temperature in original container.
  3. Include a YPI requisition.

Specimen Type: Peripheral Blood

Container/Tube: EDTA (lavender top)

Specimen Volume: 5 mL

Collection Instructions:

  1. Invert several times to mix blood.
  2. Send specimen at ambient temperature in original container.
  3. Include a YPI requisition.

Specimen Type: Fresh Tissue

Container/Tube: RPMI

Specimen Minimum Size: 2 pieces of tissue 0.2 cm3

Collection Instructions: 

  1. Collect tissue and place in RPMI.  Frozen tissue is also acceptable.
  2. Send RPMI specimen at ambient temperature.
  3. Include a YPI requisition.

Specimen Type: FFPE lymph node in block

Container/Tube: Block cassette & 1 H&E slide

Collection Instructions: 

  1. Send specimen at ambient temperature.
  2. Include a YPI requisition.

Specimen Type: FFPE lymph node cut slides

Container/Tube: 1 H&E slide plus 5-10 positively charged unstained slides cut at 5 or more microns.

Collection Instructions: 

  1. Do not use zinc fixatives.
  2. Send specimen at ambient temperature.
  3. Include a YPI requisition.

 

Specimen Rejection:

1.  Unlabeled specimens.

2.  Specimens collected in wrong container/tube.

3.  Specimens retained past viability.

4.  Specimens processed with zinc fixatives.

Forms

Specimen Transport Temperature

Ambient

Specimen Stability

Specimen Type Temperature Time
Varies Ambient

48-72 hours*

*For optimal specimen recovery, transport specimen to YPI immediately.

Day(s) Test Set Up

Monday through Friday

Test Classification and CPT Coding

81403x1 JAK2 V617F

81403x1 JAK2 Exon 12-14

81219x1 CALR

81402x1 MPL

 

The CPT codes provided with test descriptions are for informational purposes only, not billing.  Please refer to the NeoGenomics website for more detailed information.