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Test Code LAB1884 Molecular Genetics

Useful For

Detecting genetic abnormalities associated with cancer

Profile Information

Testing Options Extended Options

Prothrombin G20210A

  
ABL1 (Gleevec® resistance)  
B-Cell  
B-Cell & T-Cell  
BCL1, t(11;14)  
BCL2, t(14;18)  
BCR-ABL1, t(9;22) Reflex to ABL1
BRAF  
CEBPA  
Chimerism/DNA Fingerprinting  
Factor V Leiden R506Q  
ETV6-RUNX1 (TEL-AML1) t(12;21)  
FLT3  
IgVH Mutation  
inv(16) CBFB-MYH11  
JAK2 Exon 12-14  
JAK2 V617F Reflex to JAK2 Exon 12-14
MPL  
MPN Standard Reflex Panel  
NPM1  
PML-RARA, t(15;17)  
RUNX1-RUNX1T1 (AML1-ETO) , t(8;21)  
T-Cell  
Other:

Testing Algorithm:

  • BCR-ABL1 Reflex to ABL1: ABL1 Kinase Domain Mutation will be run when BCR-ABL1 is positive.
  • JAK2 V617 Reflex to JAK2 Exon 12-14: Exon 12-14 will be run when V617F result is negative.
  • MPN Standard Reflex Panel: JAK2 V617F is run first. JAK2 Exon 12-14 will be run when V617F is negative. MPL will be run when JAK2 Exon 12-14 is negative.

Methodology

Molecular

Performing Laboratory

Yellowstone Pathology Institute

Specimen Requirements

Specimen Type: Bone Marrow Aspirate

Container/Tube: EDTA (lavender top)

Specimen Volume: 2 mL

Collection Instructions:

  1. Invert several times to mix bone marrow.
  2. Send specimen at ambient temperature in original container.
  3. Include a YPI requisition.

Specimen Type: Peripheral Blood

Container/Tube: EDTA (lavender top)

Specimen Volume: 5 mL

Collection Instructions:

  1. Invert several times to mix blood.
  2. Send specimen at ambient temperature in original container.
  3. Include a YPI requisition.

Specimen Type: Fresh Tissue

Container/Tube: RPMI

Specimen Minimum Size: 2 pieces of tissue 0.2 cm3

Collection Instructions: 

  1. Collect tissue and place in RPMI.  Frozen tissue is also acceptable.
  2. Send RPMI specimen at ambient temperature.
  3. Include a YPI requisition.

 

Specimen Type: FFPE lymph node in block

Container/Tube: Block cassette & 1 H&E slide

Collection Instructions: 

  1. Send specimen at ambient temperature.
  2. Include a YPI requisition.

 

Specimen Type: FFPE lymph node cut slides

Container/Tube: 1 H&E slide plus 5-10 positively charged unstained slides cut at 5 or more microns.

Collection Instructions: 

  1. Do not use zinc fixatives.
  2. Send specimen at ambient temperature.
  3. Include a YPI requisition.

 

Specimen Rejection:

1.  Unlabeled specimens.

2.  Specimens collected in wrong container/tube.

3.  Specimens retained past viability.

4.  Specimens processed with zinc fixatives.



Forms

Specimen Transport Temperature

Ambient

Specimen Stability

Specimen Type Temperature Time
Varies Ambient

48-72 hours*

*For optimal specimen recovery, transport specimen to YPI immediately.

Day(s) Test Set Up

Monday through Friday

Test Classification and CPT Coding

81170x1 ABL1 Kinase

81261x1, 81264x1 B-Cell

81401x1 BCL1, t(11;14)

81402x1 BCL2 t(14;18)

81206x1, 81207x1, 81208x1 BCR-ABL1, t(9;22)

81210x1 BRAF

81218x1 CEBPA

81265x1 or 81266x1 or 81267x1 or 81268x1 Chimerism

81401x1 ETV6-RUNX1 (TEL-AML1) Translocation, t(12;21)

81479x1 FLT3

81263x1 IgVH Mutation
81401x1 inv(16), CBFB-MYH11

81403x1 JAK2 Exon 12-14 only

81270x1, 81403x1 JAK2 V617F and Exon 12-14 run concurrently or by reflex
81402x1 MPL

81270x1, 81402x1, 81403 x1 MPN Standard Reflex Panel

81310x1 NPM1

81315x1 PML-RARA Translocation, t(15;17)

81401x1 RUNX1

81340x1 T-Cell

 

The CPT codes provided with test descriptions are for informational purposes only, not billing.  Please refer to the NeoGenomics website for more detailed information.