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Test Code LBOR0179 Electron Microscopy

Additional Codes

Mayo Test Code: EM

Shipping Instructions

Whole blood specimens must arrive within 48 hours of draw.

Necessary Information

1. A completed Patient Information Sheet is required for all Electron Microscopy Consultations (see Special Instructions)

2. Tissue source required for testing to be performed.

Specimen Required

Tumor biopsies must be accompanied by a history, hematoxylin and eosin-stained slides, and a paraffin block.


Collect specimen according to the instructions in Electron Microscopy Procedures of Handling Specimens for Electron Microscopy in Special Instructions. Do not place on ice, dry ice, or freeze.


Submit only 1 of the following specimen types:


Supplies: Electron Microscopy Kit (T660)

Specimen Type: Fixed wet tissue

Container/Tube: Electron Microscopy Kit (T660) or leak-proof container

Specimen Volume: Entire specimen

Additional Information: PATHC / Pathology Consultation may be added if deemed necessary by the reviewing pathologist.


Specimen Type: Whole blood (Neuronal Ceroid Lipofuscinosis-NCL only)

Container/Tube: Electron Microscopy Kit (T660), green top (sodium heparin), or yellow top (ACD [solution B])

Specimen Volume: 5 mL

Collection Instructions: Do not transfer blood to other containers.


1. Electron Microscopy Patient Information in Special Instructions

2. Electron Microscopy Procedures of Handling Specimens for Electron Microscopy in Special Instructions

3. Pathology/Cytology Information (T707) in Special Instructions

4. If not ordering electronically, complete, print, and send a Pathology Test Request Form (T246) with the specimen (

Useful For

Identifying tumor


Diagnosing medical disorders such as storage diseases, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and primary ciliary dyskinesia

Testing Algorithm

For nontumorous renal specimens, see RPCWT / Renal Pathology Consultation, Wet Tissue for Electron Microscopy.

For platelet disorders, see PTEM / Platelet Transmission Electron Microscopic Study.

For muscle specimens, see MBX / Muscle Pathology Consultation.

For CADASIL genetic mutation testing on blood, contact Mayo Medical Laboratories.

Method Name

Electron Microscopy

Specimen Type


Specimen Minimum Volume


Specimen Stability Information

Specimen Type Temperature Time
EM Ambient (preferred)

Reject Due To








Muscle tissue, Fat pads

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information