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Test Code LBOR0149 DPYD Genotyping

Container Type


Sterile Container

Specimen Type/Requirements

EDTA Whole Blood

Extracted DNA

Specimen Volume

2.0 - 4.0 mL


Room Temperature - 72 hours

Refrigerated - 28 days

Frozen - 28 days

Transport Temperature


Performed Test Frequency

Monday through Friday


Allele-specific PCR

Performing Lab

Sanford Molecular

Analytical Time

10 - 14 days

Minimum Volume

1.0 mL



Interfering Substances

Hemolysis - NA

Lipemia - NA


This testing requires that a Patient Acknowledgement Form for Pharmacogenomics Services must be filled out for all Medicare and non-Medicare patients  and submitted with the sample for testing to be performed. In addition, Medicare patients require an ABN Form to also be submitted with the specimen.


For patients with Blue Cross Blue Shield of North Dakota coverage, a separate completed and signed Advance Member Notice is required to be submitted with the specimen.


All specimens should be sent in the original container and should not be aliquoted to another tube. In addition, the specimen submitted should ONLY be used for this testing and should not be shared with any other testing that would also utilize this specimen type.

Additional Information

Uses for Test include:


  • Estimate genetic risk of dose-related toxicity for drugs metabolized by DPYD including but not limited to 5-fluorouracil (5-FU) and capecitabine.
  • Identify genotypes indicative of a personal or family history of an adverse drug reaction or for drugs metabolized by DPYD and thereby guide drug and dose selection.

The test includes the identification of the following variant alleles:

DPYD*2, *13, rs67376798 (the SNP rs57376798 has not been given a * allele designation).


See Dihydropyrimidine Dehydrogenase (DPYD) Genotyping Medical Providers form for additional information.

See Dihydropyrimidine Dehydrogenase (DPYD) Genotyping Technical Specifications for additional information.