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Test Code BLOD0169 Dehydroepiandrosterone (DHEA), Serum

Additional Codes

Mayo Test Code: DHEA_

Useful For

Diagnosing and differential diagnosis of hyperandrogenism (in conjunction with measurements of other sex steroids)


An initial screen in adults might include dehydroepiandrosterone (DHEA)/dehydroepiandrosterone sulfate (DHEAS) and bioavailable testosterone measurement. Depending on results, this may be supplemented with measurements of sex hormone-binding globulin and occasionally other androgenic steroids (eg, 17-hydroxyprogesterone).


An adjunct in the diagnosis of congenital adrenal hyperplasia (CAH); DHEA/DHEAS measurements play a secondary role to the measurements of cortisol/cortisone, 17 alpha-hydroxyprogesterone, and androstenedione.


Diagnosing and differential diagnosis of premature adrenarche

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Collection Container/Tube:

Preferred: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Additional Information:

1. Patient's age and sex are required.

2. See Steroid Pathways in Special Instructions.

Specimen Minimum Volume

0.45 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 28 days
  Refrigerated  21 days
  Ambient  6 hours

Special Instructions

Reference Values

Premature: <40 ng/mL*

0-1 day: <11 ng/mL*

2-6 days: <8.7 ng/mL*

7 days-1 month: <5.8 ng/mL*

>1-23 months: <2.9 ng/mL*

2-5 years: <2.3 ng/mL

6-10 years: <3.4 ng/mL

11-14 years: <5.0 ng/mL

15-18 years: <6.6 ng/mL

19-30 years: <13 ng/mL

31-40 years: <10 ng/mL

41-50 years: <8.0 ng/mL

51-60 years: <6.0 ng/mL

≥61 years: <5.0 ng/mL


*Source: Dehydroepiandrosterone. In Pediatric Reference Ranges. 5th edition. Edited by SJ Soldin, C Brugnara, EC Wong. Washington, DC, AACC Press, 2005, p 75


For SI unit Reference Values, see

Day(s) and Time(s) Performed

Monday, Wednesday, Thursday, Friday; 9 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


Reject Due To


Mild OK; Gross reject


Mild OK; Gross reject


Mild OK; Gross OK


Serum gel tube

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Portions of this test are covered by patent(s) held by Quest Diagnostics